PPT Slide

Racemic MDMA has high affinity for

5-HT transporters and 5-HT2 serotonin

receptors (Battaglia et al., 1988.)

(-)-MDMA has higher affinity for

post-synaptic 5-HT receptors

(+)-MDMA has higher affinity for

5-HT transporters

(Battaglia, personal communication, 2001.)

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Notes:

Recent human studies indicate that the subjective effects of orally administered racemic MDMA can be altered by pretreatments with the the 5-HT2A antagonist ketanserin (Liechti et al., 2000b.)

However, the relationship of these subjective effects to the reinforcing effects of MDMA is unknown.

Antagonism of post-synaptic 5-HT receptors may be expected to produce a greater effect on self administration of (-)-MDMA.