PPT Slide

Drug discrimination studies suggest that the

MDMA stereoisomers may have different

subjective effects

the discriminable cue of S(+)-MDMA may be

more likely to be reported as dopaminergic

than serotonergic

(generalizes to amphetamine, not mescaline)

the stimulus properties of R(-)-MDMA may be

more likely to be reported as serotonergic

than dopaminergic

(generalizes to mescaline, not amphetamine)

(Glennon et al., 1988; Baker et al., 1995; Baker and Taylor, 1997.)

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Notes:

The discriminative stimulus profile of MDMA is complex, and differences in subject species, conditioning histories, discrimination protocols, and training doses used across these studies have often led to conflicting results.

Given the hallucinogen-like subjective effects of (-)-MDMA, we hypothesized that it would not be self-administered by rhesus monkeys.